How long does Oxycodone stay in your system?

Oxycodone is an opioid medication prescribed to treat moderate-to-severe pain. Oxycodone is intended to be taken every six hours, as needed to manage pain. Oxycodone can remain active in the bloodstream for up to 12 hours, and it often takes about 24 hours to fully process out of the body. Oxycodone is highly effective at treating pain, but carries a high risk of addiction and potential for abuse (more on Oxycodone withdrawal).

How long does Oxycodone stay in your system?

Oxycodone’s Half Life

How long a substance remains active in the system is its half-life, which is half the duration of time the drug is working. Oxycodone has a half-life of 3.2 hours (Immediate Release); this is the amount of time it takes for half a dose of Oxycodone to leave one’s the body. The drugs action is effectively eliminated from the blood in 22.5 hours. This can be much longer for those who are long term users of the drug, however.

How long does Oxycodone stay in your system?

  • Blood: Up to 24 hours
  • Saliva: Up to 2 days
  • Urine: Up to 4 days
  • Hair: Up to 90 days

Factors That Determine How Long Oxycodone Stays in the System

Several things determine how much Oxycodone is in a person’s system at any given time, such as height, age, weight, and body mass index (BMI). The amount of the substance taken, as well as the duration of use, also play a significant role in determining how long the drug will stay in the system. If someone has been taking Oxycodone for an extended time period, it will take longer than average to be removed from the system.


In conclusion, the length that Oxycodone remains in someone’s system depends on several different factors, including the type of drug test and biological factors of the patient. Different drug examinations will provide different time frames. The dose taken daily, as well as the time the patient has been on the Oxycodone also plays a role in how long the drug remains in the system.