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A Medical Approach to
Opioid Dependence
At Its Root

You've tried rehab. You've tried detox. And yet the dependence remains.

Most opioid treatments focus on managing symptoms — withdrawal, cravings, behavior — without repairing the biological systems opioids disrupt.

Talk With an ANR Specialist
or call 813-750-7470
What Is ANR?

ANR (Accelerated Neuro-Regulation)

is an advanced medical treatment designed to address opioid dependence at its biological root — not by detoxing or substituting one opioid for another, but by restoring balance to the brain's opioid-affected systems.

Unlike rehab, detox, or long-term maintenance therapies, ANR is a one-time, hospital-based medical procedure performed under deep sedation.

For more than 30 years, ANR has helped more than 25,000 patients worldwide achieve freedom from opioid dependence through a safe, effective, and humane process.

The Problem

Why Traditional Approaches Often Fall Short

Prolonged opioid use alters how the body:

  • Produces natural endorphins
  • Regulates opioid receptors
  • Responds to stress and pain

Over time, the body adapts to the constant presence of opioids. This adaptation leads to:

  • Physical dependence
  • Withdrawal symptoms when opioids are removed
  • Persistent cravings
  • High relapse risk — even in motivated individuals

Most treatments focus on helping patients endure or manage these symptoms.

ANR focuses on repairing the system that creates them.

The ANR Difference

What Makes ANR a Different Class of Opioid Addiction Treatment

ANR is designed to:

  • Restore normal endorphin signaling
  • Re-regulate opioid receptor activity
  • Resolve the biological drivers of physical withdrawal and cravings

ANR transforms the recovery landscape by addressing the underlying neurobiology of dependency and allowing patients to move forward without ongoing physiological dependence.

Find Out If ANR Is Right for You
How ANR Works

Accelerated Neuro-Regulation

ANR is a medical treatment designed to address opioid dependence at its source — not by managing the symptoms, but by repairing the system causing them, helping patients move toward a pre-dependence state without prolonged suffering or reliance on replacement opioids.

Opioid System Analysis

Detailed assessment of the patient's neurological state and receptor balance.

Accelerated Reset

Controlled medical process to restore the central nervous system's equilibrium.

Endorphin Restoration

Return toward pre-dependence state without prolonged suffering.

Step by Step

The ANR Treatment Protocol
Four Defined Stages

The therapeutic goal of ANR is endorphin system repair. This process ensures real and lasting results, freeing patients from the cycle of dependency.

01
Pre-Admission

Preparation

Before admission, our medical team works closely with the patient to improve their overall health, lifestyle, adjust their dosing, and prepare them for the procedure.

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Our preparation process includes:
  • Thorough review of medical history and current opioid use patterns
  • Optimization of health and safety conditions
  • Adjustment of medications when necessary to ensure safe treatment
  • Physical and emotional preparation of the patient and family

Every treatment plan is individualized and medically guided. Our team identifies potential risks, addresses co-existing conditions, and creates a tailored protocol to ensure the safest and most effective outcome.

02
Hospitalization & Procedure

Regulation

The patient is admitted to a fully accredited hospital ICU, where the ANR procedure is performed under deep sedation to begin re-regulating the endorphin–opioid receptor system.

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Day of treatment:
  • Morning: Admission, laboratory work, comprehensive evaluation, pre-medication
  • Midday: The patient is placed under deep, carefully monitored sedation for approximately 4–5 hours
During sedation:
  • Opioid receptor activity is precisely regulated
  • Remaining opioids are metabolized under medical supervision

Because the patient is asleep, the distress of withdrawal is not consciously experienced.

The procedure is continuously supervised by:
  • Board-certified anesthesiologists
  • Critical care physicians
  • ICU nursing staff
03
Immediate Recovery

Stabilization

The patient continues to be evaluated, and their endorphin-receptor balance can be fine-tuned during this time if required.

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Key recovery milestones:
  • Endorphin–receptor balance is assessed and adjusted if needed
  • Vital signs and neurological stability are closely monitored throughout
  • Medication protocols are fine-tuned based on individual patient response
By the next day:
  • Patients begin eating, walking, and resuming normal activity
  • Comfort levels are evaluated and managed by the care team

Most are discharged within approximately 36 hours — alert, comfortable, and free from active withdrawal.

04
Post-Discharge Support

Optimization

Recovery does not end at discharge. Our team provides structured follow-ups and ongoing support to ensure long-term success.

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Our post-treatment care includes:
  • Structured follow-ups (in-person during stabilization, then remote)
  • Guidance on physical activity, nutrition, and lifestyle optimization
  • Support to help maintain long-term neurological stability
  • Ongoing access to our medical team for questions and adjustments

This phase helps patients transition confidently back to everyday life – without dependence. Many patients report progressive improvement in sleep, energy, and emotional well-being in the weeks following treatment.

Safety Is Central to ANR

ANR Is a Proven Medical Procedure —
Not Rapid Detox, Not Experimental

It is a medical treatment performed exclusively:

  • In ICU settings of fully accredited hospitals
  • With advanced continuous monitoring
  • By experienced, board-certified physicians
ANR has demonstrated an exceptional long-term safety record over more than three decades.
ICU Settings
Performed exclusively in fully accredited hospital ICUs.
Advanced Monitoring
Real-time monitoring throughout the entire procedure.
Board-Certified Physicians
Experienced anesthesiologists and critical care physicians.
30+ Year Safety Record
More than 25,000 patients worldwide treated with an exceptional safety profile.
Eligibility

Who ANR May Be
Appropriate For

ANR may be suitable for individuals dependent on:
Prescription OpioidsOxycodone, Hydrocodone, Morphine, etc.
Methadone
BuprenorphineSuboxone®, Subutex®, Zubsolv®
Heroin
Fentanyl
Tramadol
KratomIncluding 7-OH compounds
More
Find Out If ANR Is Right for You
Each patient undergoes a comprehensive medical evaluation
Expected Outcomes

By removing the primary biological drivers of dependence, ANR allows patients to focus on rebuilding their lives.

Resolution of withdrawal symptoms
Absence of physical cravings
Improved mental clarity and emotional stability
Patients return to their lives opioid-free within days
ANR vs. Traditional Methods

A Different Class of Treatment

Next Generation

The ANR Treatment

Accelerated Neuro-Regulation

  • Treats the root cause of dependency (the damaged endorphin–receptor system).
  • Performed only in a hospital ICU with full monitoring.
  • Performed by board-certified anesthesiologists & critical care physicians.
  • Fully sedated. You do NOT feel withdrawal.
  • Relapse rates in the single digits by targeting the biological source of dependency.
  • No prolonged suffering. The procedure is designed to be humane and efficient.
One procedure. Lasting freedom.
Symptom-Driven

Traditional Treatments

Rehab, Detox, MAT

  • Manages symptoms only; does not address the underlying neurological cause.
  • Performed in outpatient or residential settings, often without appropriate medical support.
  • Overseen by counselors, therapists, or general practitioners.
  • Patients experience full withdrawal — often severe and prolonged.
  • High relapse rates even among highly motivated patients.
  • Extended detox timelines with significant discomfort and uncertainty.
Ongoing management required.
Clinical Evidence & Research

Grounded in Decades of Science

ANR is grounded in decades of clinical experience and research into opioid dependence, neurobiology, and endogenous opioid systems.

In Progress
Ongoing Research
Additional clinical studies on ANR's mechanisms and outcomes are underway. These upcoming peer-reviewed publications will help expand the evidence base regarding long-term restoration and patient outcomes.
Clinical Study 2004

Accelerated Neuroregulation for Therapy of Opiate Dependency

Published in Medical Journal of Indonesia · Vol. 13, No. 1, pp. 53–58

Location: Indonesia

Overview

This clinical study reports on the experience of using accelerated neuroregulation to reverse both physical and psychological opioid dependency. A total of 361 heroin-dependent patients were admitted to an ICU setting for a full 24–36 hour treatment protocol, including a 6-hour pre-procedure medication process followed by the ANR procedure under general anesthesia.

Key Findings
361
Patients treated — all successfully detoxified
0
Adverse anesthetic events reported
100%
Craving elimination in patients who completed naltrexone maintenance
10 mo
Timeframe for craving to fully disappear with naltrexone
Methodology

After comprehensive psychological and medical examination, patients were hospitalized in an ICU for 24–36 hours. The protocol included a 6-hour pre-procedure medication regimen (clonidine, diazepam, omeprazole, octreotide, ondansetron, and others). Anesthesia was induced with midazolam and propofol IV, maintained via propofol infusion for 3.5–5 hours depending on severity, while naltrexone and supportive medications were administered. Upon discharge the following day, patients were prescribed oral naltrexone for 10–12 months.

Conclusion

Accelerated neuroregulation, combined with naltrexone maintenance treatment of 10–12 months, was found to be highly effective for detoxification and abolishing craving in heroin-dependent patients. Side effects were generally mild and self-limiting — the primary challenge identified was patient compliance with the long-term oral naltrexone regimen, with 45.9% completing the full course.

Authors

S. Sunatrio, L. Rachmat, G. Darmansyah, Y. Thedja

Citation
Sunatrio S, Rachmat L, Darmansyah G, Thedja Y. Accelerated neuroregulation for therapy of opiate dependency. Med J Indones. 2004;13(1):53–58.
Read Full Study
Retrospective Clinical Study 2019

ANR (Accelerated Neuro Regulation): Abstinence Through Regulation of Opioid Receptors

Published in Suchtmedizin

Location: Switzerland

Original title (German)

Durch Regulation der Opioidrezeptoren zur Abstinenz – ANR (Accelerated Neuro Regulation)

Retrospective Clinical Study 2023

Hemodynamic and Pulmonary Safety Profile of the Accelerated Neuro-Regulation Procedure

Published in NeuroRegulation Journal · Vol. 10, No. 4, pp. 253–259

Location: USA

Overview

This retrospective safety study evaluated the hemodynamic and pulmonary stability of patients undergoing the ANR procedure at the ANR Clinic in Florida. The research examined vital physiological markers — heart rate, blood pressure, and oxygen saturation — recorded at baseline, during, and after the procedure to establish a formal safety profile.

Key Findings
50
Patients assessed — no exclusions applied
Stable
Hemodynamic response throughout procedure
±12–14
BPM max heart rate deviation from baseline
Normal
SpO₂ and blood pressure ranges maintained
Methodology

A retrospective chart review was conducted on 50 consecutive patients who underwent the ANR procedure between November 2020 and February 2021. Each patient’s mean heart rate, systolic and diastolic blood pressure, and oxygen saturation were recorded at baseline, during, and after the ANR procedure. The maximum deviation (delta) from baseline levels was calculated across the sample to assess the physiological impact of the treatment.

Conclusion

The study demonstrates that ANR procedures are a safe and effective treatment for opioid use disorder, based on the stability of hemodynamic and pulmonary physiological response data. Heart rate remained within normal physiological ranges throughout the procedure, with average deviations of only 12 BPM below and 14 BPM above baseline — well within acceptable clinical parameters. Blood pressure and oxygen saturation similarly showed stable readings throughout.

Authors

Andre Waismann, Albert Kabemba, Olga Medowska, R. Salzman, C. Philpott, Milesh M. Patel

Citation
Waismann, A., Kabemba, A., Medowska, O., Salzman, R., Philpott, C., & Patel, M. M. (2023). Hemodynamic and pulmonary safety profile of the accelerated neuroregulation procedure. NeuroRegulation, 10(4), 253–259. https://doi.org/10.15540/nr.10.4.253
Read Full Study
Why Am I Only Hearing About This Now?

30 Years in the Making — Now Available in the U.S.

If ANR works this well, why isn't it everywhere? It's a fair question — and the answer is simple: ANR was developed and refined internationally for over three decades before being introduced to the United States.

Unlike mass-market pharmaceutical treatments, ANR is a specialized, ICU-based medical procedure.

It doesn't fit neatly into the traditional rehab or medication-assisted treatment model — which is exactly why it goes beyond what other approaches can achieve.

For years, ANR was available only in select international hospitals. The procedure was continuously refined, studied, and improved — building an extensive track record of safety and patient outcomes across thousands of cases worldwide.

Now, with a dedicated U.S.-based facility, board-certified physicians and specialized medical teams, ANR is finally accessible to American patients — without traveling overseas.

Late 1990sPioneered Internationally

ANR treatment pioneered and first administered in hospital ICU settings internationally.

2000sGlobal Expansion

Thousands of patients treated across Europe, Asia, and other international centers. Clinical protocols refined continuously. Initial clinical findings are published.

2010sResearch Published

Additional research published. Safety profile validated across decades of clinical use.

2020sAvailable in the U.S.

U.S.-based ANR center established, bringing the procedure to American patients.

FAQ

Common
Questions

We understand you may have many questions. Here are answers to the most common ones.

Still have questions?
Our team is here to help with a free, confidential consultation.
Call 813-750-7470 →
How much does ANR treatment cost, and is it covered by insurance?

The ANR treatment costs $21,500, which includes a personalized treatment plan, in-patient hospitalization, 24/7 medical care and monitoring, and more. As an elective procedure, it is not currently covered by insurance. However, we offer different financing options to help you cover the cost of the treatment.

How long does the ANR procedure take?

The ANR treatment takes just a few days. The hospitalization for the ANR treatment lasts only 36 hours on average, while the procedure itself takes about 4–6 hours. Once you’re discharged from the hospital, our team will continue to work with you to facilitate your journey to lifelong recovery.

Where are ANR clinics located?

ANR currently operates several facilities, with treatment locations in the United States, Switzerland, Israel, Georgia, and Brazil. In the United States, ANR is offered at DeSoto Memorial Hospital in Arcadia, Florida. For more information, don’t hesitate to call us at 813-750-7470—we’ll be happy to assist you!

Will I feel withdrawal during the ANR procedure?

No, during the ANR procedure, the patient is under deep sedation in the ICU, so they do not consciously experience withdrawal as the body is being medically stabilized and the endorphin–opioid receptor system is re-regulated.

Testimonials

Real Patients. Real Results.

Every patient who comes to ANR has a story — most have tried other treatments before. Here's what they experienced.

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Speak with a knowledgeable specialist who can answer your questions and help determine if ANR is right for you or your loved one.

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