Since the 1970s, methadone has been primarily used to treat opioid addiction. Still, it is no less addictive than other opioids. It’s common for people who take it—be it to relieve pain or opioid cravings—to experience uncomfortable methadone withdrawal symptoms when trying to quit it.
While many people continue to take methadone for decades, it is possible to make a full recovery from all opioids—including this one. Often, the first step to achieving a lasting recovery is learning what your options are and how to detox from methadone the right way.
What Is Methadone?
Methadone is a long-acting synthetic opioid prescribed to treat opioid use disorder (OUD) and pain that cannot be managed with weaker medications. Available as an injectable liquid, powder, oral solution, and tablet, this drug is sold under its generic name and several brand names, including Methadose® and Dolophine®.
When used for pain relief, methadone disrupts the transmission of pain signals between the body and the brain, reducing the perception of pain. It can also be used in medication-assisted treatment (MAT) alongside counseling and behavioral therapy to help people addicted to other opioids manage opioid withdrawal symptoms.
When taken as intended, methadone doesn’t cause euphoria and can also blunt the euphoric effects of other opioids. By suppressing cravings and other withdrawal symptoms, this drug helps reduce the risk of relapse and overdose.
However, even though methadone can help people quit more potent opioids, it isn’t a cure for opioid addiction—those who take it risk developing dependence and addiction. As a Schedule II controlled substance, methadone carries a high potential for abuse, opioid dependency, and addiction. To minimize these risks, you should always follow your doctor’s instructions when taking it.
Long-term use increases tolerance: your body may require more of the drug for the same effect, and stopping or reducing use can trigger withdrawal. Taking methadone strictly as prescribed minimizes—but does not eliminate—the risk of opioid addiction.
Methadone Withdrawal Symptoms
If you stop taking methadone after using it regularly for some time, you may experience methadone withdrawal symptoms—a sign that you’ve become dependent on the drug.
Like all opioids, methadone has addictive properties and can lead to tolerance, physical dependence, and addiction. If you take it for a long time and especially if you abuse it (e.g., take larger doses than prescribed), your body can eventually become used to it.
If you try to discontinue methadone use, you’ll experience uncomfortable withdrawal symptoms, which can be both physical and psychological. Tapering off methadone can result in a milder withdrawal, whereas quitting “cold turkey” may lead to intense symptoms, some of which may require medical attention.
The more severe your methadone withdrawal symptoms are, the higher the risk of relapse. Relapsing after a period of sobriety greatly increases the risk of a potentially fatal opioid overdose. You should never attempt to quit this drug abruptly or detox from methadone without medical supervision.
Some of the most common methadone withdrawal symptoms are:
Methadone Withdrawal Timeline
The methadone withdrawal timeline looks different for everyone, as the severity and duration of methadone withdrawal symptoms depend on various individual factors. These include your methadone dosage, consumption method, and metabolic rate.
Here’s an example of a typical methadone withdrawal timeline:
Since methadone is a long-acting opioid, most people will experience the first methadone withdrawal symptoms within 30 hours (more or less) after their last dose. In the beginning, methadone withdrawal can feel no different than the flu. A runny nose, fever, chills, and body aches are common during this period.
After the first couple of days, methadone withdrawal symptoms become increasingly intense and usually peak within 5–7 days after the last dose. However, it may take longer for your symptoms to peak if you have a severe addiction to methadone.
Besides the symptoms mentioned above, at this time, you may also experience:
- Anxiety
- Cravings
- Nausea
- Difficulty sleeping
- Vomiting
- Depression
- Agitation
- Rapid heartbeat
Methadone withdrawal symptoms tend to gradually subside after reaching their peak, and most people will no longer suffer from them past day 10 of quitting methadone. However, some may continue to struggle with psychological withdrawal symptoms—cravings, anxiety, depression, etc.—for up to a month or even longer.
Methadone Post-Acute Withdrawal Syndrome (PAWS)
Methadone post-acute withdrawal syndrome (PAWS) happens when your withdrawal symptoms persist for weeks, months, or even years after quitting the medication.
While most people overcome the symptoms of methadone withdrawal in just over a week, this isn’t the case for those with PAWS. The effects of methadone PAWS are primarily psychological, with the most common symptoms being:
- Poor concentration
- Interrupted sleeping patterns
- Indifference
- Lethargy
- Loss of appetite
- Mood swings
- Worsening of mental illnesses like depression, anxiety, and bipolar disorder
When you’re suffering from PAWS, it may feel as if your struggle with opioid addiction will never end. However, it is not necessarily a permanent condition. Receiving proper medical help is key to overcoming it and reducing the risk of relapse.
How to Manage Methadone Withdrawal Symptoms
The best and most effective way to manage methadone withdrawal symptoms is to seek help from medical professionals. Whether you’re taking methadone for pain relief or as part of opioid addiction treatment, you should not stop taking it without consulting your doctor—doing so can lead to severe symptoms, increasing the risk of relapse, methadone overdose, and death.
While relapse is one of the greatest dangers of detoxing at home without medical care, it isn’t the only one. Some symptoms may be mild enough to be helped with home remedies (e.g., over-the-counter medications). However, others can put your life on the line—especially if you have underlying medical conditions.
Unfortunately, there have been cases of people dying during opioid withdrawal, including from complications such as heart failure caused by extreme dehydration.
Receiving professional treatment for methadone withdrawal and addiction can minimize the risk of such adverse events. If you experience persistent nausea and vomiting after quitting this medication, seek medical attention immediately.
Risks and Dangers of Taking Methadone
Although methadone is one of the three FDA-approved medications for medication-assisted treatment (MAT), it doesn’t come without risk. As with all opioids, methadone use can lead to abuse, tolerance, dependence, addiction, overdose, and even death.
Methadone can cause a potentially life-threatening overdose, especially when mixed with other substances such as benzodiazepines, antibiotics, and alcohol.
In the United States, methadone overdose deaths make up a relatively small percentage of all opioid-involved overdose deaths. Still, Centers for Disease Control and Prevention data on provisional drug overdose death counts shows that around 3,000 people lose their lives to methadone each year.
Moreover, methadone can cause various side effects, ranging from mildly uncomfortable to potentially life-threatening. These may include:
- Breathing problems
- Dry mouth
- Weight gain or weight loss
- Mood changes
- Impaired vision
- Stomach issues
- Seizures
- Itchy skin
- Sedation
Inform your doctor about any side effects you experience. If your side effects are severe (e.g., difficulty breathing or swallowing, extreme drowsiness, etc.), call 911 immediately.
How to Detox From Methadone
You should seek medical help to detox from methadone safely.
Detoxing from methadone can be a lengthy process, which is why rapid detox might seem like an attractive solution. This anesthesia-assisted method quickly clears methadone from your system using opioid-blocking drugs such as naloxone. Since advanced rapid detox is done under sedation, it can reduce the intensity of withdrawal symptoms—but it can cost upwards of $20,000, and many patients relapse because rapid detox addresses symptoms rather than the underlying brain changes of dependency.
Meanwhile, Accelerated Neuro-Regulation (ANR) is a comprehensive opioid addiction treatment designed to restore balance in the endorphin-receptor system and address the physiologic roots of dependence. In doing so, it eliminates withdrawal symptoms and negates the risk of relapse when compared with detox-only approaches.
Methadone Rapid Detox vs. ANR Treatment
The ANR treatment is superior to methadone rapid detox, especially in terms of effectiveness and safety. By today’s standards, rapid methadone detox is outdated: it treats symptoms of addiction but not the cause, which often leads to relapse.
ANR is an ultra-modern opioid addiction treatment—the only one that tackles the root cause of opioid dependency by bringing your endorphin-receptor system back to balance. Unlike methadone rapid detox, ANR eliminates withdrawal symptoms, thereby negating the risk of relapse.
Furthermore, rapid methadone detox is often performed in clinics. In contrast, ANR is carried out in an ICU setting of accredited hospitals by critical care physicians, nurses, and other board-certified medical professionals—and it is tailored to each patient individually, so even those with complex medical issues can undergo it safely.
Here’s a detailed side-by-side comparison of methadone rapid detox and the ANR treatment:
ANR Opioid Treatment for Methadone Addiction
Accelerated Neuro-Regulation (ANR) is currently the only treatment that can successfully restore endorphin-receptor balance in people with opioid dependency.
While rapid detox attempts to counteract the effects of methadone withdrawal, ANR targets the deep causes of addiction and withdrawal by focusing on the physiologic mechanism behind methadone dependency. Most importantly, unlike many traditional detox treatments, ANR doesn’t involve replacement drugs that can lead to addiction.
Because of this, ANR allows patients to recover without fear of further symptoms, relapse, or lengthy hospital stays. Most patients return to an opioid-free life after a short stay at one of our centers.
For your convenience, you can find ANR centers around the world, including:
- DeSoto Memorial Hospital, Arcadia, Florida
- ANR Europe Thun, Switzerland
- New Vision University Hospital, Tbilisi, Georgia
Ready to take the first step toward an opioid-free life? Contact us today for a free consultation!
Key Takeaways
Whether you’ve been taking methadone for two months or two years, refrain from quitting it by yourself. Your doctor can help you navigate the methadone withdrawal and detox process safely and effectively.
Now, let’s reiterate the key points we covered:
- Methadone is an opioid medication that is used to treat pain and OUD, but it is also highly addictive.
- Methadone withdrawal usually starts within the first 36 hours after taking the last dose and lasts around 10 days, though some symptoms may persist for up to a month or even longer.
- Some common methadone withdrawal symptoms are fever, nausea, abdominal pain, diarrhea, cravings, and depression.
Methadone Withdrawal & Detox FAQ
1. How long can you be on methadone?
If you opt for methadone maintenance therapy (MMT), you can be on methadone for anywhere between several months and several years. Some people addicted to opioids take methadone for 20 years or even more. If you decide to quit this drug, work with your doctor to gradually taper off it, as stopping it abruptly can cause severe withdrawal symptoms.
2. What are the signs of methadone use disorder?
Some signs of methadone use disorder include having trouble controlling methadone use, taking it more often or in larger quantities than prescribed, and experiencing withdrawal symptoms, such as cravings and nausea, when trying to quit the drug.
3. What is ANR opioid treatment?
ANR, which stands for Accelerated Neuro-Regulation, is a revolutionary opioid addiction treatment that can help you overcome opioid dependence within days. Unlike other therapies, ANR reverses the effects opioids have on the brain, eliminating the risk of relapse. It also doesn’t involve potentially addictive opioid-replacement drugs, such as buprenorphine.
4. When do methadone withdrawal symptoms start?
Methadone withdrawal symptoms typically start within the first 36 hours after the last dose and include flu-like symptoms such as fever, watery eyes, and muscle aches.
5. How long does methadone withdrawal last?
How long methadone withdrawal lasts depends on the extent of your methadone use, whether or not you’re undergoing any treatment for methadone withdrawal and addiction, and other such factors. For most people, acute methadone withdrawal symptoms resolve within 10 days of quitting the medication.
6. Is methadone an opioid pain medication?
Yes, methadone is an opioid pain medication that can be prescribed to relieve pain that cannot be treated with non-opioid painkillers. It can also be used as part of medication-assisted treatment (MAT) to help people addicted to more potent opioids manage withdrawal symptoms.
Additional Information
