Methadone Withdrawal – Symptoms, Timeline & Opioid Drug Treatment

Methadone – what’s the risk?

Methadone is a synthetic opioid painkiller that is also used as medication-assisted treatment for opiate addiction (also known as methadone maintenance treatment). If taken as instructed by a doctor, the drug can be useful in treating pain or for the management of opioid withdrawal. However, it does have the potential for misuse, abuse, and opioid dependency, which can lead to increased tolerance.

When one tolerance to an opioid, they will likely feel that they must take a higher dose of the medication more frequently to experience its full effect. When this occurs, and the user attempts to stop taking the drug, they may experience uncomfortable, painful symptoms known as opiate withdrawal. These opiate withdrawal symptoms are often what cause people to become addicted to opioid drugs, as they feel that they must undertake long-term use to avoid the withdrawal process. If you or someone you know is experiencing dependence or opioid use disorder, it is advised to seek even though people often seek drug rehab instead.

Methadone as a prescription medication

As methadone is a long-acting opioid, a doctor may prescribe enough of the drug to last a patient months or even years as part of a long-term treatment plan. This long-term maintenance therapy ensures that they are no longer in pain and/or successfully recover from the effects of opioid use disorder. Of course, this creates the risk of misuse, as it becomes the patient’s responsibility to manage their dosage.

To reduce the risk of irreversible harm during medical detox, a doctor may prescribe a lower methadone dosage for a patient recovering from opioid addiction. As each person responds differently to the drug, the doctor would then determine through careful observation and evidence-based care, the best methadone dose to keep the patient on (if any).

Signs & symptoms of opioid withdrawal

Methadone withdrawal symptoms usually begin 24-48 hours after the last methadone dosage. Withdrawal from methadone may last for three to six weeks but can take longer for those with severe methadone addictions. These withdrawal symptoms can be extremely uncomfortable, increasing the risk of relapse in an attempt to prevent the withdrawal symptoms from continuing.

Signs and symptoms of withdrawal may include:

  • Anxiety, depression, and indifference
  • Paranoia and hallucinations
  • Attention-deficit
  • Insomnia or trouble sleeping
  • Dilated pupils
  • Flu-like symptoms
  • Muscle aches and pains
  • Diarrhea, nausea, and vomiting
  • Low blood pressure and/or heart rate
  • Drug cravings
  • Decreased energy level

In some cases, these symptoms can be life-threatening. If you, loved , or someone you know is experiencing potentially life-threatening effects of withdrawal, contact emergency care services immediately.

(Read here on how long does Methadone stay in your system).

Recovery timeline from symptoms of withdrawalThe withdrawal process and severity of dependence may vary from patient to patient as each person’s body is unique and responds to methadone differently. The efficacy of withdrawal management and treatment may also be influenced by the dosage and the length of methadone exposure. Symptoms may at first intensify with time and then subside until the patient has completely weaned off methadone.

Methadone Withdrawal Timeline

Days 1-2:

This is when most people will begin to experience withdrawal symptoms. Flu-like symptoms such as changes in body temperature and body aches can be expected, in addition to nausea and rapid heart rate.

Days 2-10:

During this period, patients tend to enter the acute withdrawal phase, where symptoms are at their worst. The patient will often experience restlessness, insomnia, anxiety, intense drug cravings, differences in blood pressure, and even hallucinations.

Days 11-21:

At this point, severe symptoms usually begin to subside. Despite this, patients are often left to deal with continued psychological symptoms, which remain prevalent. Additional symptoms one can expect during this period of time include lethargy, indifference, anxiety, depression, intense cravings, and a strong urge to relapse.

Long-term effects:

If the patient’s body has developed opioid tolerance, it may take months for the patient to wean off methadone completely. This is due to the common practice of slowly decreasing the patient’s methadone dosage on a weekly or basis. Although gradually tapering the dosage can result in a reduced intensity of withdrawal symptoms, the patient may suffer long-term adverse health effects due to the extended period of methadone exposure.

Such long-term harmful health consequences may include:

  • Low heart rate and/or changes in daily blood pressure
  • Respiratory depression
  • Nerve, liver, and brain damage
  • Mood swings
  • Eating disorders
  • Decreased attention span and inability to concentrate
  • Sexual function and menstruation changes
  • Increased severity of opioid drug dependence and addiction

Post-acute withdrawal syndrome – signs, symptoms, and long-term treatment

While many people can overcome the symptoms of withdrawal in just over a week, for, symptoms can last much longer. Post-acute withdrawal symptoms (PAWS) cause patients to feel the effects of withdrawal for several weeks, months, or even years. Although the effects of PAWS are mostly psychologicalcausing or exacerbating mental illnesses like depression, anxiety, and bipolar disorder can also cause poor concentration, interruptions to sleeping patterns, indifference, lethargy, loss of appetite, and mood swings.

PAWS is not necessarily a permanent condition; it can be overcome with the help of an effective treatment schedule.

Rapid Detox for Opioid Addiction 

Detoxing from methadone can be a lengthy process, which is why rapid detox might seem like an attractive solution. This anesthesia-assisted opioid detox method quickly wipes methadone out of your system with the use of opioid-blocking drugs (e.g., naloxone). Since advanced rapid detox is done under sedation, it can reduce the intensity of methadone withdrawal symptoms.

Since rapid detox can cost upwards of $20,000, you might assume that it guarantees lifelong results. However, besides side effects such as nausea and vomiting, many patients relapse after the procedure. This happens because methadone rapid detox only tackles the symptoms of methadone dependency instead of its underlying cause – chemical brain changes.

ANR Opioid Treatment – Treating Methadone Dependency with ANR 

Accelerated Neuro-Regulation (ANR) is currently the only treatment that can successfully restore the endorphin-receptor balance in people with opioid dependency. 

While rapid detox attempts to counteract the effects of methadone withdrawal, the ANR treatment targets the deep causes of addiction and withdrawal by focusing on the physiologic mechanism behind methadone dependency. Most importantly, unlike many traditional detox treatments, ANR doesn’t involve replacement drugs that can lead to addiction.

Because of this, ANR allows patients to recover without fear of further symptoms, relapse, or having to spend weeks in hospital settings. Most patients return to an opioid-free life after a weekend stay at one of our centers! 

ANR Clinic has treatment providers that offer the medication-assisted detox process in:

  • DeSoto Memorial Hospital, Arcadia, Florida
  • ANR Europe Thun, Switzerland
  • New Vision University Hospital, Tbilisi, Georgia

If you’re looking to recover from methadone dependency, contact us for a free consultation with one of our opioid dependency experts!


Methadone maintenance treatment and other medication-assisted treatments are used by doctors to help addicts recover from their opioid use disorder. Buprenorphine is another medication that is used for the same reason. Despite the prevalence of these treatments, there is always a risk of further abuse when opioids enter the body.

There are many health risks associated with opioid use. Opioids are highly addictive—in fact, there is currently an opioid epidemic occurring in the United States that is responsible for many deaths and a high relapse rate. Because methadone is an opioid, it can lead to abuse, dependence, and addiction. If addiction happens, the risk of overdose or severe withdrawal symptoms can emerge.
Withdrawal will typically begin in the first 1-2 days after methadone discontinuation. Symptoms include nausea, increased heart rate, and flu-like symptoms such as fever, chills, and body aches.
For most, physical symptoms of methadone withdrawal will begin to subside in a little over a week, with the severity of withdrawal symptoms peaking after at least 2 days of the user’s last dose of methadone. For some, symptoms may last weeks, months, or even years. This is known as post-acute withdrawal syndrome (PAWS). The length of time someone experiences opioid withdrawal symptoms largely comes down to the individual themselves and the treatment options they choose to use. The recovery period lasts only a few days at an ANR treatment center.
Mixing alcohol and opioid drugs can be extremely dangerous. As well as the risk of causing alcohol addiction, alcohol withdrawal symptoms, and co-occurring substance use disorders, abusing these two substances can also have adverse effects on a person’s physical health, causing liver failure/damage, respiratory depression, a decline in brain health, and in some cases, death.
Yes. While it is often used as an opioid medication-assisted addiction treatment administered in a methadone clinic or hospital setting, many doctors favor it as an effective medication for pain relief in the United States.
There are many signs that you can look out for to help identify opioid use disorder and addiction to methadone. See here to learn more about methadone addiction.
is an evidence-based care treatment of drug dependence/addiction in closed settings by restoring the endorphin-receptor balance to regular levels. While other detox programs such as inpatient treatment, residential treatment programs, outpatient treatment require long-term treatment and a strict schedule to produce results, ANR is a much faster addiction treatment that typically takes effect in only a few days without the need for a long-term treatment schedule or large amounts of time spent in a hospital setting.

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