How Long Does Vicodin Stay in Your System?

Vicodin contains the over-the-counter medication acetaminophen, the active ingredient in Tylenol, and the opioid painkiller hydrocodone. It is a prescription medication dispensed to treat moderate-to-severe pain. Vicodin is meant to be taken every six hours as needed to manage pain. Vicodin can remain active in the bloodstream for up to 12 hours, and it often takes about 24 hours to fully process out of the body. (More about Vicodin withdrawal)

How Long Does Vicodin Stay in Your System

Vicodin’s Half Life

How long a drug remains active in the system is its half-life, which is half the duration of time the drug is actively working. Vicodin has a half-life of 3.8 hours, meaning this is the amount of time it takes for half a dose of Vicodin to leave one’s system. It will take an average of 19 hours to eliminate all of the Vicodin from the system. However, this can take longer for those who are long term users of the drug.

How long does Vicodin stay in your system?

  • Blood: Up to 24 hours
  • Saliva: Up to two days
  • Urine: Up to four days
  • Hair: Up to 90 days

Factors That Determine How Long Vicodin Stays in the System

Several things determine how much Vicodin is in a person’s system at any given time, such age, height, weight, and body mass index (BMI). The amount of the drug taken, as well as the duration also play a significant role. If someone has been abusing Vicodin by taking heavy doses for an extended period of time, it will accumulate in the fatty tissue, where it will be stored for several days.


In conclusion, the length that Vicodin remains in someone’s system depends on several different factors, including the type of drug test administered and individual biological factors of the patient. Different drug tests will provide different time frames, with a hair follicle test typically being able to detect the presence of drugs much longer than a urine or saliva test. The dosage, as well as the length of time the patient has been on the drug also determines how long the drug remains in the system, among other factors.