How long does Methadone stay in your system?

Methadone is a prescription medication dispensed to treat moderate-to-severe pain, as well as the treatment of drug addiction through helping prevent withdrawal symptoms caused by stopping other opioids. Methadone is meant to be taken daily, typically in the morning for drug withdrawal treatment purposes, or around every 8-12 hours for pain management purposes. Methadone can remain active in the bloodstream for up to 24 hours, and it often takes about 59 hours to fully process out of the body (more about Methadone withdrawal).

How long does Methadone stay in your system?

Methadone’s Half Life

How long a drug remains active in the system is its half-life, which is half the duration of time the drug is actively working. Methadone has a half-life of 24 hours in opioid dependent patients, and even longer (approximately 55 hours) in opioid naïve patients. The half-life is the amount of time it takes for half a dose of Methadone to leave one’s body. It will take an average of 59 hours to eliminate all of the Methadone from the system. However, this may take even longer for patients who are long term users of the drug.

How long does Methadone stay in your system?

  • Blood: Up to 24 hours
  • Saliva: Up to 10 days
  • Urine: Up to 12 days
  • Hair: Up to 90 days

Factors That Determine How Long Methadone Stays in the System

Numerous aspects determine how much Methadone is in a person’s system at any given time, such age, height, weight, and body mass index (BMI). The amount of the drug being used, as well as the extent also play a crucial role. If someone has been taking Methadone in higher doses for an extended period of time, it may take much longer than average to remove the Methadone from their body.


In conclusion, the time that Methadone remains in someone’s system depends on many factors, including the type of drug screen administered and individual factors of the patient. Different drug tests will provide different time frame’s; this is key to take into consideration. The daily dose, as well as the length of time the patient has been taking Methadone ca also determine how long the drug remains in the system, among other factors.