Fentanyl Dependency & Addiction Treatment

Fentanyl Withdrawal Treatment Center

ANR Clinic is Now in the US

Fentanyl, also known as Sublimaze, Duragesic, Fentora, Actiq, Subsys, and Abstral, is a synthetic opioid. On the street, fentanyl is created in clandestine labs and often used as a cutting agent for heroin. While heroin derived from morphine, a natural substance removed from the seed of the opium poppy plant, fentanyl is synthetic and 50 to 100 times more potent than morphine. (1,2) 

Fentanyl is a potent, synthetic opioid analgesic with a rapid onset and short duration of action. It is a strong agonist at the μ-opioid receptors. Historically, it has been used to treat breakthrough pain and is commonly used in pre-procedures as a pain reliever as well as an anesthetic in combination with a benzodiazepine. Fentanyl is approximately 80 to 100 times more potent than morphine and roughly 40 to 50 times more potent than pharmaceutical grade heroin. Fentanyl was first synthesized by Paul Janssen in 1960 following the medical inception of pethidine several years earlier. Janssen developed fentanyl by assaying analogues of the structurally related drug pethidine for opioid activity. The widespread use of fentanyl triggered the production of fentanyl citrate, which entered the clinical practice as a general anaesthetic under the trade name Sublimaze in the 1960s. Following this, many other fentanyl analogues were developed and introduced into medical practice, including sufentanil, alfentanil, remifentanil, and lofentanil.

According to the CDC, the number of deaths involving heroin combined with synthetic narcotics has been increasing steadily since 2014. The statistics indicate that the use of fentanyl drives the increase in overdose deaths involving heroin. 

Fentanyl-laced counterfeit pills resembling prescription sedatives and painkillers, such as Xanax and OxyContin, have also risen in popularity due to their potency, producing the desired high for cheap. A lethal dose of fentanyl is just between 2 to 3 milligrams, and many users will use it unknowingly. Unsurprisingly, the CDC has reported fentanyl as the leading drug of the opioid epidemic for overdose deaths across America.

Fentanyl does have legally recognized medicinal uses in the United States and therefore classified as a Schedule II controlled substance by the DEA. Schedule II drugs still have a very high potential for abuse, dependency, and addiction despite their indicated medical uses.

Typically, a doctor will prescribe fentanyl to patients who need chronic pain relief, which may be recovering from surgery, or those suffering from cancer. If you are physically tolerant to other opioids, you may be prescribed fentanyl to manage severe chronic pain. Prescription fentanyl can be taken as a lozenge or sublingual tablet, as a nasal spray or swab, given as an injectable, or absorbed through the skin in the form of a transdermal patch. Fentanyl is a rapid-acting opioid. Like heroin, morphine, and other opioid drugs, fentanyl works by binding to the body’s opioid receptors, which are found in areas of the brain responsible for regulating pain and emotions. (3) 

Fentanyl functions in the same manner as other opioids, binding with neurochemical transmitters in the central nervous system, to block the transmission of pain signals. It binds to the same brain receptors as endorphins, which occur naturally in our bodies, such as those related to feelings of euphoria. With repeated exposure, the human body will quickly adapt to this increased endorphin production by increasing the number of endorphin receptors. However, when our endorphin levels drop, feelings of depression, pain, and physical cravings occur. These neurochemical changes are the central physiological cause of addiction.

Someone who does not take fentanyl as prescribed, or abuses opioids, creates a measurable chemical imbalance in the brain. Initially, using fentanyl may provide a euphoric high, numbing both physical and mental pain. The brain will attempt to restore balance, but our natural endorphin production will not be able to keep up with the amount of receptors it has created due to prolonged drug use. The result? You will require larger amounts of fentanyl to satisfy the brain’s endorphin receptors. This describes a tolerance to fentanyl, which inevitably leads to fentanyl dependence (the need to continue taking a drug to avoid a Fentanyl withdrawal syndrome) and addiction (intense cravings and compulsive drug use).

When you use and abuse narcotics such as fentanyl, the endorphin-receptor balance is physically altered, making it increasingly difficult to feel pleasure from anything besides your drug of choice. It is not a matter of personality or willpower; your brain is changed in a neuro-biophysical manner, and professional treatment, such as Accelerated Neuro- Regulation, is the medically proven answer to reverse the imbalance that drives your dependency or addiction to fentanyl.

Detox from Fentanyl

Fentanyl is considered heroin’s more potent and lethal cousin. Once an individual begins taking fentanyl long-term, the drug may fail to have the desired effect after some time. This occurrence is known as a physical tolerance to fentanyl and happens when our brain creates more receptors than there are endorphins to bind with. The brain is constantly seeking a state of balance and can be thought of simply in terms of supply and demand. By supplying the brain with an external opioid, you increase the endorphin receptors, which means an increase in demand. This is an extremely dangerous state as the brain may demand more fentanyl to satisfy its craving, but the amount the heart, and body as a whole, can withstand is not nearly as much as the endorphin-receptor system now requires. 

The abuse of an opioid such as fentanyl lowers the body’s natural endorphin production levels while simultaneously increasing the number of receptors. When the demand is high, but the supply is low, symptoms of opioid dependency or addiction may arise as the individual is attempting to manage a physiological need for the drug.

The two decisions a person abusing fentanyl faced with are to either A) up to their dosage and continue to abuse the drug or B) refuse to provide the body with the drug by quitting, often cold-turkey, and experiencing the unpleasant physical symptoms known as Fentanyl withdrawal syndrome.

It is worth noting, that any traditional detox from fentanyl, whether it be an inpatient program at a rehab facility or a “Rapid Detox” from opioids, does not solve the root of the problem, which we addressed earlier: a biophysical change in the balance of the brain’s endorphin-receptor system. 

Instead of merely managing the symptoms associated with withdrawals, Accelerated Neuro-Regulation can treat the underlying cause in a clinically proven, effective, and humane manner. ANR is the only medical answer to outdated practices that keep someone who finds his or herself addicted to opioids, in a perpetual cycle of using, abusing, and relapsing. We have the answer to help you or your loved one detox from fentanyl without even experiencing the painful discomfort of Fentanyl withdrawal symptoms. 

Imagine addiction treatment being as simple as making an appointment, receiving your treatment under the care of trained and licensed medical professionals, and being able to resume your day-to-day life within about 30 hours. 

Just think: one weekend of your life at the ANR Clinic can change the course of your entire future. By targeting the physiological mechanism behind dependency, patients can begin to enjoy life again without the looming fear of an inevitable relapse. You can do this all without missing out on weeknight dinners with family, losing your job, or disrupting your weekly routines.

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Fast & Rapid Fentanyl Withdrawal

During the 1990s, Dr. Andre Waismann, founder of the ANR Clinic and treatment, helped lay the foundation for opioid detox treatment with the development of “Rapid Detox.”

“Rapid Detox” became one of the leading methods for treating addiction symptoms in drug rehab centers and inpatient clinics. Still used today, it utilizes anesthesia to manage the intense symptoms of drug withdrawal. However, Dr. Waismann soon realized that many of these programs implemented “Rapid Detox” without the knowledge to do so safely and effectively. In turn, patients experienced negative side effects and did not achieve the desired outcome of sobriety without consequences such as relapse. 

In seeking a more advanced solution for his patients, Dr. Waismann developed what is now known as Accelerated Neuro-Regulation treatment (ANR). He saw detoxification was actually the initial step of recovery, and not the full answer, as removing the opioids from the body does not do anything to treat the brain’s underlying imbalance. It wasn’t long before Dr. Waismann identified the root of opioid dependency and addiction: Changes to the structure and function of the brain due to addiction may persist for months and, if left untreated, often result in relapse. The root of the problem needs to be resolved to achieve real, lasting results in the treatment of opioid addiction.

As a result, ANR became the only treatment currently addressing the brain’s underlying cause of addiction. 

ANR restores balance in the brain and restores freedom to patient lives. Recovery from an opioid such as fentanyl is possible without constantly fearing relapse. By evaluating each patient’s individual endorphin-receptor balance, the ANR method of treatment for opioid withdrawal is tailored to each person’s neuro-biological needs, making it an incredibly effective method of treatment over Rapid Detox.

Accelerated Neuro-Regulation is the most cutting edge answer to address opioid dependency, backed by science. To date, over 24,000 patients and counting have successfully treated. By bringing ANR to the United States, Dr. Waismann hopes to help put an end to the current opioid crisis our country is facing. As fentanyl abuse continues to top the charts in opioid-related deaths, ANR is the solution to an otherwise grim future. Doctors using ANR internationally have seen promising patient responses and post-treatment results. The outcomes for patients who receive ANR treatment have been overwhelmingly positive. They continue to support the use of Accelerated Neuro-Regulation as the new standard of care for opioid addiction. 

Fentanyl Withdrawal Symptoms

Fentanyl withdrawal is unpleasant and can include anxiety, nausea, vomiting, and abdominal pain. While not life-threatening, symptoms of Fentanyl withdrawal can certainly be intense and severe. The FDA reports the following as potential side effects of the opioid withdrawal syndrome that occurs when fentanyl leaves the bloodstream:

  • Anxiety and agitation
  • Sweating/Body chills
  • Restlessness
  • Runny nose
  • Back and muscle aches or weakness
  • Stomach cramps
  • Body hair standing on end or bristling
  • Nausea and/or vomiting
  • Diarrhea
  • Elevated heart and respiratory rates
  • Hypertension
  • Insomnia

Fentanyl Withdrawal Timeline

Opioid withdrawal syndrome will usually peak during the first few days and will level off within approximately one week when you begin weaning or detoxing from fentanyl. While ANR treats Fentanyl withdrawal symptoms under anesthesia, allowing the patient to avoid the discomfort and pain of active Fentanyl withdrawal, other opioid addiction treatment options may follow a timeline where symptoms will gradually become lessened over a week. Fentanyl withdrawal symptoms will vary on a case by case basis depending on the frequency of drug use, dose, and genetics. A timeline for stopping the use of fentanyl, either cold turkey or by tapering, may look like the following:

  • Days 1-2

The first signs of Fentanyl withdrawal will surface anywhere within the first eight hours up to two days. Symptoms usually have a rather rapid onset and will typically begin to peak at around 36 hours.

  • Days 2-4

After the first day and a half of stopping fentanyl, symptoms will be at their strongest but should start to subside after about three days.

  • Day 5-7

After approximately five days, you should begin to feel an improvement. In some cases, however, it may be weeks before individuals are feeling healthy and able to function normally again.

  • 7 Weeks and Beyond

Physical symptoms, including sensitivity to pain, may still be present for several weeks or even months. Psychological symptoms, such as cravings, depression, irritability, anxiety, and difficulty sleeping, may also persist for beyond the week-long detox. Individuals who use fentanyl for chronic purposes will need to find a different way to manage pain.

One of the greatest advantages of ANR is being able to bypass much of the physical and psychological pain that is inevitable when you decide to stop abusing opioids such as fentanyl and undergo the Fentanyl withdrawal process. With traditional opioid withdrawal detox, an extended stay is recommended at a residential treatment center, adding more potential stress to the individual’s life as commitments such as family and work will be put on hold. The Accelerated Neuro-Regulation method only requires about a day and a half stay to complete. Instead of potentially weeks of suffering, individuals can begin to return to their daily living, knowing that their endorphin-receptor system is rebalanced and that they no longer need to fear to battle a lifelong addiction. 

Fentanyl Addiction Treatment

The US is in the midst of an opioid overdose epidemic. If you or someone you know needs help, effective treatment is available and can save lives. 

Physical and mental symptoms that occur after stopping or reducing intake of opioids, a substance found in certain prescription pain medications and illegal drugs like heroin. 

Opioid withdrawal develops after the body has become accustomed to a certain level of opioids. Opioids are found in certain prescription pain medications or drugs like heroin. Symptoms of opioid withdrawal include anxiety, nausea, vomiting, or abdominal pain. While symptoms can be severe, they aren’t life-threatening. 
Treatment includes supportive care as well as medications to address symptoms and prevent complications.

The most popular available treatment for fentanyl dependency in the United States is medication therapy. Opioid withdrawal syndrome often involves a doctor prescribing methadone, buprenorphine, or naltrexone in a drug detoxification facility or rehab in order to aid in the tapering or weaning off of a substance like fentanyl. The issue with “detoxing” is that even if done successfully, it leaves the brain and its endorphins in a deregulated state. 

The ANR treatment method for Fentanyl addiction is performed in approximately 4-5 hours. A hospital stay lasting about 30 hours in total is required for the patient to be properly monitored pre and post-procedure. In the U.S., ANR is completed at Landmark Hospital in Naples, Florida. 

Once you make the call and are determined to be a candidate for ANR, your treatment will be scheduled. On the day of your treatment, you will be admitted into the hospital’s ANR unit. All patients undergo an evaluation, a lab screening, and a medical exam in order to tailor the treatment on an individual basis.

The lab screening will include taking vital signs (blood pressure and heart rate, for example), liver function tests, kidney function evaluation, blood counts, and other important markers. These tests may sound extensive but are necessary to deliver the most appropriate and effective care. 

Once the patient’s lab and exam results are evaluated, a decision will be made if he or she will be capable of undergoing the procedure. If considered an appropriate candidate, the patient is given pre-medication to maximize comfort. The physician will prepare for the procedure, and the patient will be placed under deep sedation. Under the supervision of Dr. Waismann, the patient will be monitored and cared for by intensive care nurses and anesthesiologists for approximately 4-5 hours.

Accelerated Neuro-Regulation involves the cleansing and blocking of opioid receptors using naltrexone. Following an extensive review of the individual patient’s receptor status, the procedure is tailored accordingly in order to achieve the desired result. Factors that may determine different needs include the length of time using fentanyl, dosage amount, and overall health. ANR effectively induces Fentanyl withdrawal symptoms while the patient is sedated. In doing so, the opioid dependency is essentially cleansed from the body, all without having to experience the painful side effects which accompany opioid withdrawal treatment. The treatment process will continue until the physician determines that balance has been restored. It is then time to stop sedation, regain consciousness, and officially begin the road to recovery. 

Once awake and opioid-free, the patient will carefully be monitored for the following 24-30 hours. The physician and intensive care nurses will educate the patient on what recovery measures to follow in order to begin recovery safely and healthily. If needed, endorphin-receptor balance will continue to be adjusted during the 1-2 day inpatient stay as well. During this time, patients will continue to be cared for and also will be encouraged to continue their daily living activities such as walking around, eating, and showering.

Upon discharge, patients leave with the peace of knowing that they are no longer dependent on fentanyl, and can begin to live a healthier, more joyous life. 

Fentanyl Rehab Near Me

When searching for a fentanyl rehab near you, there are many factors to take into consideration. Arguably, the most important deciding factor is how effective a treatment will be. In the U.S., fentanyl detox centers and rehabs are only equipped to treat Fentanyl withdrawal symptoms. Stays can be lengthy, and patients must experience the unpleasant side effects of opioid withdrawal syndrome. 

The fear of withdrawal from fentanyl is understandable and often prevents individuals from entering a rehab facility or detox program. Entering a long-term residential facility to overcome fentanyl addiction is a huge commitment financially and time-wise. 

Thanks to advances in modern medicine, the ANR Clinic in Naples, Florida, can help you overcome your opioid addiction once and for all, and with the promise of being able to tend to your regular routines and obligations. Over just one weekend, and without having to miss out on life’s special events, time with friends and family, or work, ANR treatment affords you the ability to get back to normal life that same week, without any added stressors. 

Fentanyl Withdrawal Facility

The Accelerated Neuro-Regulation treatment is performed by a team of highly qualified medical professionals, in a modern and comfortable hospital ICU. Hundreds of thousands of times with great success. The treatment is unlike any other currently available in the United States, as it is considered the most effective and efficient treatment for fentanyl dependency. It is through addressing the brain’s imbalance, that addiction is defeated. Recovery from fentanyl addiction is possible with ANR.

If previous attempts at weaning from fentanyl, or tapering did not work for you, it is essential to know that it is not your fault. Up until now, fentanyl addiction treatment at rehab facilities has been centered around symptom management and has ignored the driving force behind opioid dependency: an imbalanced brain! Simply detoxing the drug from your system still leaves your brain with more receptors than endorphins, which was the physical driving force behind your dependency and/or addiction, to begin with. Fentanyl tolerance, dependence, and addiction are manifestations of brain changes resulting from chronic fentanyl use. So long as the imbalance remains, individuals will continue to experience the stronghold of fentanyl dependency and addiction. Treatment at the ANR Clinic in Florida, restores the brain’s altered endorphin-receptor balance, tackling the underlying cause of your need for fentanyl, and leaving you free from opioid cravings, dependency, and addiction. 


  1. Volpe DA, Tobin GAM, Mellon RD, et al. Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs. Regul Toxicol Pharmacol. 2011;59(3):385-390. doi:10.1016/j.yrtph.2010.12.007
  2. Higashikawa Y, Suzuki S. Studies on 1-(2-phenethyl)-4-(N-propionylanilino)piperidine (fentanyl) and its related compounds. VI. Structure-analgesic activity relationship for fentanyl, methyl-substituted fentanyl, and other analogs. Forensic Toxicol. 2008;26(1):1-5. doi:10.1007/s11419-007-0039-1
  3. Drug and Chemical Evaluation Section, Office of Diversion Control, Drug Enforcement Administration. Acetyl fentanyl Fact Sheet. July 2015. http://www.deadiversion.usdoj.gov/drug_chem_info/acetylfentanyl.pdf.

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